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Depending on dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI) by several P450 cytochromes

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Autophagy has been reported to be involved in rotenone-mediated neurotoxicity, based on LC3-II decreases 53

For example, markers of enhanced oxidative stress and diminished methylation ability, such as reduced S-adenosylmethionine/S-adenosylhomocysteine and GSH/GSSG ratios, have been detected in the plasma of autistic children [114,115,116]