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BBB ECs have high transendothelial electrical resistance, which significantly limits both paracellular and transcellular passage ( FIGURE 1 Damage to the BBB can increase the permeability of the walls of the blood vessels within the brain, leading to the influx of neurotoxic and pro-inflammatory molecules, and invoking local inflammatory responses ( This review provides an introduction to BBB imaging methods in humans by answering three key questions: (2

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doi: 10.1136/jmedgenet-2012-100972 73 GongMNZhouWWilliamsPLThompsonBTPothierLBoycePet al