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NP tissue from CD and NCD dogs show differences in gene expression profiles [14] and, therefore, future studies should aim at determining whether CD and NCD dogs also respond differently on IVD regenerative treatments

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Mechanistically, M27 binds DDB1, a component of host Cullin4RING E3s (CRL4), to induce polyubiquitination of STAT2, resulting in its rapid proteasomal degradation (Trilling et al , 2011

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