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nicotine, a highly addictive substance found in tobacco products, can lead to dependence, making it challenging to quit

For 2MN, strong but not fully confirmed (*) evidence was obtained

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Another study using an air-liquid interface (ALI) to assess the cytotoxic effects on human bronchial epithelial cells, showed that IQOS exposure induced higher cytotoxicity (reduced metabolic activity) than e-cigarettes or air controls but lower than combustible cigarettes 22