PKM2 provides tumour cells with a metabolic advantage by allowing the use of phosphometabolites upstream of pyruvate as precursors for synthesising nucleic acids, amino acids as well as lipids
Bioessays 35 , 965973 (2013)
A selective non-competitive inhibitor of VMAT2 VMAT1 is a different isoform expressed in peripheral neuroendocrine cells (adrenal chromaffin cells, interneurons of sympathetic ganglia, and enterochromaffin cells that store serotonin in the GI tract)
Immediately after administration (within 2 min), serial GSH MEGA-PRESS spectra were obtained over the course of up to 62 min post dose (11 min per scan, for a total of three to five measurements post dose)
doi:10.1164/ajrccm.161.6.9907112 Wang F, Li C, Liu W, Jin Y (2014) Modulation of microRNA expression by volatile organic compounds in mouse lung