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Research indicates that autophagy activation may enhance drug resistance in tumor cells during chemotherapy, as autophagy can clear drug-induced cellular damage, thereby protecting tumor cell survival ( 3.4 Epigenetic modifications In recent years, research has demonstrated that epigenetic modifications play a crucial role in the drug resistance of HGSOC, including changes in DNA methylation, histone modifications, and non-coding RNA expression

Future research could investigate potential dietary adjustments to enhance L-carnitine consumption, considering the elevated levels of L-carnitine found in meat and dairy items

10.1016/j.cell.2016.02.035 37 ChenL.ZhangJ.LiC.WangZ.LiJ.ZhaoD.et al