Some studies have suggested that rapid improvements in glycemic control with semaglutide may be associated with temporary worsening of diabetic retinopathy in certain patients, particularly those with pre-existing retinopathy
B12 injections generally work faster and suit people with absorption problems or severe deficiency, while supplements are a suitable, lower-cost option for mild, diet-related shortfalls
Higher doses (12.515 mg/week) may be used in subsequent phases if tolerated and clinically indicated
(Van Wagoner et al., JAMA, 2017) The practical implications of this data matter more than the headline number
Allergic: anaphylaxis, urticaria, shortness of breath, wheezing, angioedema CNS: headache, dizziness, agitation, anxiety Dermatologic: rash, erythema, pruritus Ophthalmic: diplopia 7