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Procedure Participants were recruited between September 2022 and February 2023 using online research recruitment platforms (e.g

Abbreviations ALK: Anaplastic lymphoma kinase APOBEC: Apolipoprotein B mRNA editing catalytic polypeptide AR: Androgen receptor ARID1A: AT-rich interaction domain 1A ATM: Ataxia-telangiectasia mutated gene BRCA1: Breast cancer gene 1 CDK1: Cyclin dependent kinase 1 CDK2: Cyclin dependent kinase 2 CDKN2A: Cyclin dependent kinase inhibitor 2A CK2: Casein kinase 2 COPD: Chronic obstructive pulmonary disease COSMIC: Catalogue of somatic mutations in cancer CTLA4: Cytotoxic T-lymphocyte associated antigen 4 CYP21A2: Cytochrome P450 family 21 subfamily A member 2 DNA: Deoxyribonucleic acid EGFR: Epidermal growth factor receptor FANCG: Fanconi anemia complementation group G gene GWAS: Genome-wide associated study KRAS: Kirsten rat sarcoma viral oncogene homolog LCNS: Lung cancer in never smokers LUAD: Lung adenocarcinoma MRCA: Most recent common ancestor MSH6: MutS homolog 6 NF1: Neurofibromatosis type 1 Nitro-PAH: Nitrated polycyclic aromatic hydrocarbon NKX2-1: Homeodomain NK2 homeobox 1 NOTCH1: Neurogenic locus notch homolog protein 1 NSCLC: Non-small cell lung cancer PAH: Polycyclic aromatic hydrocarbon PD-L1: Programmed death ligand 1 PFS: Progression free survival PM2.5: Particulate matter smaller than 2.5 m POLD1: Polymerase delta 1 PRS: Polygenic risk score PV: Pathogenic germline variants RB1: Retinoblastoma 1 RET: Rearranged during transfection RNA: Ribonucleic acid ROS: Reactive oxygen species RTK/RAS/RAF: Receptor tyrosine kinase/rat sarcoma protein/rapidly accelerated fibrosarcoma protein SBS: Single base substitution SCNA: Somatic copy number alteration SHS: Second hand smoke TIM3: T cell immunoglobulin and mucin domain 3 TKI: Tyrosine kinase inhibitor TMB: Tumor mutational burden TMEM127: Transmembrane protein 127 TP53: Tumor protein 53 UV: Ultraviolet References McCarthy WJ, Meza R, Jeon J, Moolgavkar S

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