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The preservation of normal glucose-insulin dynamics with AOD-9604 is important for appetite neutrality, as blood sugar fluctuations and insulin spikes are major drivers of hunger and cravings

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2 Methods 2.1 Animals and procedures The animal experimental procedures were approved by the Animal Care and Use Committee of Oujiang Laboratory (SYXK2023-0047, OJLAB22121609), and were carried out in strict accordance with the National Institutes of Health Guidelines for the Use of Laboratory Animals