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Melatonin has been studied in randomized controlled trials, meta-analyses, jet lag studies, and insomnia research involving thousands of participants

: Maeda, K., Fukuda, M

The patients who benefit most are those in steep deficits (1,2001,400 calories daily for women, 1,6001,800 for men) who present with elevated liver enzymes or fatigue despite adequate macronutrient intake

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Foundational evidence here comes from animal models showing that CoQ10 supplementation can restore oocyte mitochondrial function in aged mice, 3 with subsequent human trials beginning to map the same pathway in clinical settings (see CoQ10 section below)