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Nature Medicine 2025

Interestingly, 2 of these studies were performed in patients who had been admitted for acute cardiovascular disease (myocardial ischaemia), and no short or long-term adverse cardiovascular effects appeared in the group of subjects that used bupropion, compared to the group that received standard care.18,19 These data were confirmed in a recent metaanalysis and in a new randomized, controlled clinical trial.20,21 A recent randomized, double-blind, controlled clinical trial examined the efficacy of a smoking treatment programme in a group of smokers who received intensive counselling for smoking cessation during admission, followed by continued counselling with automated interactive voice response telephone calls after discharge, as well as the treatment of their choice for a period of 3 months (NRT, bupropion or varenicline)

He fought without a mouthpiece for much of his career, and once took an uppercut that made him bite through his tongue