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Ethics statement The research protocol was approved by the hospital ethics committee (Ethics review document: 2020001), and all the research subjects signed informed consent form

chronic, maintenance of weight balance Synergy with leptin , amylin restores leptin sensitivity in obese models Synergy with CCK and GLP-1 , multi-pulse pathways of appetite suppression No tolerance , chronic administration of amylin preserves efficacy Why it matters: Lutzs review article established the scientific basis for amylin pharmacotherapy of obesity

Since we do not expect that TAT-DAT NT would have opposite effects at different doses, we did not perform in vivo microdialysis for different doses of TAT-DAT NT

Studies show that NNMT is highly expressed in the liver of obese individuals

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