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Insulin receptors are a class of special protein heterodimers, composed of a calcitonin receptor (CTR) combined with three homologous receptor activity-modifying proteins (RAMP 1,2,3), forming three subtypes (AMY1, AMY2, AMY3)

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During secretory granule biogenesis, SCG2 and CHGA condense to form large aggregates, while SCG3 functions as a trans-membrane sorting adaptor 22

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