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The 200-fold-greater potency of LR3 versus insulin in cell-culture systems coupled with the molecules resistance to enzymatic degradation in serum-free media underlies its adoption as a substitute for native IGF-1 in animal-component-free cell-culture protocols

At 8 weeks post-infection, the percent of lung involvement in granuloma formation of the untreated mice increased to an average of about 60% (Figure 8B)