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Screening was performed with a TGR assay using DTNB, including a 15 min preincubation of recombinant enzyme, inhibitor, and NADPH before addition of substrate (Table 3)

Compared to use of a placebo (84 patients) in this trial, use of -tocopherol (85 patients) significantly slowed progression of Alzheimer's dementia, evidenced by significant improvements on the Blessed Dementia Scale and time to institutionalization (122)

More specifically in this study, we showed compounds like SFN, which modulate thiol levels, could be used in combination with artemisinin to extend the useful lifespan of artemisinin-based treatments

ADP, adenosine diphosphate, ATP, Adenosine triphosphate