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Over the last decade, physicians have seen the emergence of EVALI e-cigarette or vaping product use-associated lung injury a sometimes-fatal condition linked to contaminants such as THC derivatives and certain oils found in vape cartridges

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It plays a fundamental role in the T-cell-mediated responses by attenuating co-stimulatory signaling, limiting immunosurveillance, and promoting immune homeostasis ( CTLA-4 may act independently or synergistically with other coinhibitory pathways to support tumorigenesis through direct or indirect mechanisms