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74,77,78 In this context, a high NAD + /NADH ratio has been found in human iPSCs and embryonic stem cells (ESCs)

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Of particular note is that several cohort studies have found that high folate status (typically indicated by elevated serum folate concentrations) is associated with apparently exacerbated outcomes in individuals with low vitamin B12 status (typically indicated by low serum B12 concentration or elevated MMA concentrations), including higher risk of anemia and cognitive impairment (79), and accentuated elevations of blood homocysteine and MMA (80, 81)

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