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doi: 10.1016/j.ccr.2007.12.027

doi: 10.3390/ijms27062876

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To clarify how integrated safety data operates in practice, the following areas are addressed: Clinical safety monitoring during development Pharmacovigilance Adverse Event Assessment Post-approval safety oversight and signal detection Regulatory documentation and data traceability Clinical Safety Monitoring During Drug Development Clinical teams monitor safety data continuously during trials to detect emerging risks early