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Amide bonds typically favour the trans configuration due to steric and electronic factors

It can also take a little longer for some to feel the full effects

Around weeks 3-6 things start to shift slightlyskin texture improves, healing speeds up, and theres a subtle sense that your baseline is improving

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans