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Heart Failure: Chronic smoking damages the heart muscle, leading to heart failure

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Nicotine PK parameters for each product (C max (ng/ml), AUC t (AUC 0-t ) (h*ng/ml), T 1/2(z) (minutes), AUC 0-90 (h*ng/ml), AUC 0-inf (h*ng/ml), C last (ng/ml)) were calculated by Non-Compartmental Analysis (NCA) using Phoenix WinNonlin software version 8.1 (Certara, USA)

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