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Autophagy, Metabolic, and Other Emerging Pathways Several peptides act through less conventional mechanisms, including regulation of autophagy, activation of metabolic receptors, and other mechanisms that remain to be fully elucidated (Figure 3E)

The 1-methylnicotinamide product of NNMT may itself have biological activities (including potential insulin resistance-promoting effects), and reducing its production through NNMT inhibition may contribute to metabolic improvements

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They reduce appetite, improve blood sugar control, and enhance metabolic health

This improves their quality of life