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To enable safe clinical exploration, pharmacodynamic monitoring should be embedded from the outset, using biomarkers of lipid peroxidation and cellular redox status to verify on-lesion activity, coupled with early indicators of marrow and mitochondrial injury to guide dose adjustment (101)

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The impact of ROS and OS is thought to fluctuate with varying amounts of active smoke exposure [282]

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Glutathione is highly recognized as an efficient antioxidant that plays an important part in purifying the body, improving immune health and fighting against environmental pollutants