Activated Caspase-3 cleaves gasdermin E (GSDME), releasing its N-terminal pore-forming domain (PFD) from the C-terminal inhibitory structure, thereby forming membrane pores and inducing GSDME-mediated pyroptosis (46)
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Push hard on one pathway and it quietly compensates through another, which is why we chase a goal like younger skin through several routes at once, like antioxidants, sleep, protein, training, and daily sun protection
*Correspondence: Yanling Huang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers