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( g ) HTML:TML ratio was assessed in FT282-CCNE1 cells treated with the IDH1 inhibitor and supplemented with KG (n = 8 technical replicates representative from 2 independent experiments)

Enhanced endurance during cardio due to increased glycogen storage in muscles

SOD and GPx activities of disease and control group were 6.15 and 8.11, 463.9 and 472.34 nmole/min/mL unit, respectively

Disruption of this integrated network (e.g., via ferroptosis inhibitors targeting ACSL4/GPX4, anti-inflammatory agents blocking HMGB1/IL-33, or HIF modulators balancing hypoxia adaptation) can break the pathogenic cycle, highlighting the therapeutic potential of targeting the networks central nodes rather than individual pathways

The MR-Base platform supports systematic causal inference across the human phenome