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Folic acid and vitamin B12 administration in CKD, why not

But for vegans, supplements are a must to avoid deficiency. Malabsorption-Related Deficiency Protocols Malabsorption-related B12 deficiency needs a special treatment

By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways

PMID 25875118

Elderly people due to impaired intestinal absorption and children, premenopausal women, and pregnant women whose diets are low in animal foods are all at increased risk