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Firstly, upon contact with target cells, CTLs trigger degranulation, releasing perforin, which forms membrane channels in target cells, facilitating the entry of effector molecules such as granzymes, TNF, and secretory ATP, ultimately leading to target cell death

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Lawrences love and admiration for both her husband and son (their family letters to each other are spirited, funny, and warm) inspired in her a concern for the sons and husbands of others, for American manhood generally, its moral constitution and the example it set