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However, IL-15-mediated upregulation of ZO-1 and ZO-2 expression was independent of the IL-2R subunit, whereas phosphorylation of occludin and enhanced membrane association of claudin-1 and claudin-2 by IL-15 required the presence of the IL-2R subunit

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For a chronic condition like MS where peptide research might continue for months or years, total costs add up significantly and should be part of any informed decision-making process