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Based on these promising pre-clinical data, a first-in-human phase I trial (Electrical Stimulation of the Dentate Nucleus Area (EDEN) for Improvement of Upper Extremity Hemiparesis Due to Ischemic Stroke: A Safety and Feasibility Study) has recently received approval and is actively enrolling (ClinicalTrials.gov Identifier: NCT02835443)

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Safety profile comparable to GLP-1 agonists when properly titrated [12]

Peptides tend to act more locally or on specific cell types