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Theres also some research into DSIPs potential in neuroprotective, anticonvulsive, and antinociceptive (pain reduction) effects

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While specific downregulation kinetics for Dihexa haven't been thoroughly characterized in published literature, research on HGF and c-Met signaling in other contexts suggests receptor density begins declining within 2448 hours of sustained agonist exposure, with maximum downregulation occurring around 72 hours

publish landmark study demonstrating Dihexa's synaptogenic properties via HGF/c-Met activation at Washington State University [McCoy et al., 2013]