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The overall orientation shifted from CuA towards the L4 region

This fragment oligomerizes and inserts into the plasma membrane, forming pores that disrupt membrane integrity, increase ion influx, and lead to cell swelling and eventual rupture (Kovacs and Miao, 2017)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Mueller J.K., Mller W.E

Retinol, strong acids, and Vitamin C lead to irritation when used together, which slows results