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It depends on what you are treating

Supplementation studies indicate that Se can improve TSH levels in Se-deficient individuals with subclinical hypothyroidism

Furthermore, our collaborators also identified an altered metabolic pathway in reactive astrocytes, where the urea cycle leads to enhanced GABA production, further impacting memory function 59

While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

Pickart L: The human tri-peptide GHK and tissue remodeling