Ann Oncol 24(4):10791087 Wu S, Gao Q, Zhao P, Gao Y, Xi Y, Wang X, Liang Y, Shi H, Ma Y (2016) Sulforaphane produces antidepressant- and anxiolytic-like effects in adult mice
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Although the release of these proteins into the cytosol is expected to trigger apoptosis, this form of cell death is negligible in APAP-induced hepatotoxicity, as shown by the absence of caspases activation and the inability of caspase inhibitors to protect against APAP-induced liver injury ( in vitro after treatment with APAP and fructose, which acts as a glycolytic substrate to generate ATP and glycine as a membrane stabilizer ( As MPT and JNK are key players in APAP-mediated acute liver failure, it is unclear whether mitochondrial dysfunction and JNK are engaged in low dose APAP exposure without liver injury
