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SLC7A11-ROS/KG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression

doi: 10.1186/s10020-023-00614-9 29

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In canonical Wnt/-catenin signaling, the secreted Wnt ligands bind with the Frizzled receptor, which further inactivates glycogen synthase kinase-3 (GSK-3), which is an enzyme responsible for the ubiquitination-mediated degradation of -catenin 4,5