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Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

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If NNMT inhibition both restores adipocyte energy expenditure (promoting fat reduction) and supports myogenic differentiation (preserving or enhancing muscle), the net body composition effect could be recomposition simultaneous fat loss and lean mass preservation