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Peptides with fewer residues are more susceptible to rapid enzymatic degradation, leading to shorter systemic exposure. Fosgerau & Hoffmann, Drug Discovery Today Half-Life Each peptide has a defined biological half-life the time it takes for half of the substance to be eliminated from the bloodstream

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In murine macrophages, glucocorticoids generally suppress production of pro-inflammatory eicosanoids (e.g., prostaglandins and leukotrienes), and pro-inflammatory cytokines (e.g., IL-1, IL-6, TNF, and IL-12), and they inhibit leukocyte migration (85, 9094)