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In the morning, always follow with a dedicated broad-spectrum SPF 30 or higher sunscreen on the face and all exposed body areas without exception this is absolutely essential when using any Kojic Acid or brightening active product as these actives increase the skin's UV sensitivity and failure to use daily SPF will reverse your brightening progress and worsen hyperpigmentation

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Finally, the MC4R plays an important role in the production of the neuropeptides YY and glucagon-like peptide 1 by the enteroendocrine cells (43-47)