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Mendelian randomization The researchers used a special method to measure causal effect, since they werent looking at the connection between smoking and alcohol use directly

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The FDA, which first considered this policy under Scott Gottlieb during the first Trump administration, has abandoned the idea of gradually phasing in the nicotine reduction because that would initially result in "compensatory smoking." That is, current smokers would be apt to inhale more deeply, take more or bigger puffs, or consume more cigarettes to get the nicotine dose to which they are accustomed, which would increase their exposure to the toxins and carcinogens in tobacco smoke

As for the first half, the company said that results reflect "ongoing macroeconomic pressures", especially in the US