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Regulatory note: DSIP is not approved by the FDA or EMA for any indication it is an unapproved research chemical with no established safety profile [6]

Tirzepatide increases heart rate modestly (average 24 bpm in clinical trials), while growth hormone effects on cardiac function require monitoring in susceptible individuals

Cagrilintide has no boxed warning because it has no approved label, not because its long-term safety has been demonstrated