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While they are safe for almost everyone, some contraindications include those who are breastfeeding or pregnant, or who may have an allergy or sensitivity to any of the ingredients included in the shot

Methionine, inositol, and choline are not typically supplemented orally at therapeutic doses in isolation, so the MIC component still adds value even if B12 is covered

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They are vicsous and can enhance the drug residence time in the nasal cavity, which improves the IN delivery of drugs to the brain