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Low levels of glutathione have been implicated in both acute and chronic health problems, including health problems associated with severe COVID-19 infection

This along with the elevated level of peroxide is a perfect storm for generation of hydroxyl radical, the most reactive and destructive form of ROS

Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms

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Typically, the nyctohemeral rhythm of this hormone can be forecasted by measuring salivary, urinary sulfatoxymelatonin, and plasma levels