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STAT3 was silenced by gene transfection technology to verify the core role of STAT3 in GHK Cu treatment of UC

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In 1891, it was found to be useful to treat malaria, thus making methylene blue "the first synthetic compound ever used as an antiseptic in clinical therapy and the first antiseptic dye to be used therapeutically," according to the authors of a Medicinal Research Reviews paper on the compound

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