They are not inevitable or irreversible, but they do warrant attention rather than being treated as an acceptable side effect to push through
Most patients see measurable improvement within 48 weeks, with continued and often substantial improvement continuing over a 12-week protocol
Venugopal S, MD, Issa GC, MD, Konopleva M, MD, PhD, DiNardo CD, MD, MSCE, Borthakur G, MD, Jabbour EJ, MD, Pemmaraju N, MD, Yilmaz M, MD, Short NJ, MD, Maiti A, MBBS, Sasaki K, MD, PhD, Masarova L, MD, Pierce SA, BSN, BA, Takahashi K, MD, PhD, Tang G, MD, PhD, Loghavi S, MD, Andreeff M , MD, PhD, Bhalla KN, MD, Garcia-Manero G, MD, Ravandi F, MBBS, Kantarjian H, MD, Daver N, MD
Moreover, kynurenine competes with other amino acids, such as methionine and leucine, that are transported by Slc7a5 to T cells, thereby impairing T cell-mediated immune responses [284]
In comparison to the docking conformation, the chelation site of CuB shifted from the ether oxygen to the hydroxymethyl group, with the hydroxyphenyl group forming a hydrogen bond with S356