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Mechanistically, Legumain mediates the chaperone-mediated autophagy of GPX4 via HSP90/HSC70, decreasing GPX4 abundance and promoting AKI-associated ferroptosis ( in vitro I/R model alleviated ferroptosis by regulating the GSHGPX4 pathway ( /GSHGPX4 axis as a critical therapeutic node in renal I/R injury: interventions targeting pathway-related genes or enhancing key protein levels boost renal antioxidant capacity, offering novel strategies to mitigate I/R-induced kidney damage

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In addition, mushrooms are deemed a viable source of prebiotics as they contain different polysaccharides, such as chitin, chitosan, hemicellulose, xylans, mannans, galactans, and - and -glucans [228]