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For explants to acclimate to ex vitro conditions, physiological and anatomical adaptations must take place (Ldo et al

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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012

10.1007/s10654-024-01138-038992218 114 Yang Y, Zhang X, Jin Z, et al