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This prothrombotic alteration in TF/TFPI could be mediated by decreased NO bioavailability [67]

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In the middle of the seventeenth century the capacity of the pipe increased with the increased duties on tobacco, and, until the era of Dutch William [late 17th century], kept on enlarging until it appears to have satisfied the most inveterate smoker 6 The NPAoE similarly suggests that the cost of tobacco during the early period of adoption in England impacted the pipe bowl size

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