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Who Should Avoid It Known copper sensitivity or Wilson's disease Active skin infections at application site Pregnancy or breastfeeding (injectable) Stop Right Away If You Notice Severe skin irritation, burning, or persistent redness Allergic reactions (rash, swelling, difficulty breathing) Unusual skin discoloration or staining Persistent metallic taste (injectable) Worsening of skin condition after 4-6 weeks Milder Signs to Watch For How Long Should a GHK-Cu Cycle Last

TABLE 1 Therapeutic mechanisms and targets of natural products targeting mitochondria in kidney diseases