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PLoS One 9 , e93932 (2014)

NAM : Nicotinamide

11Forman HJ, Zhang H, Rinna A

"Patients taking oral tranexamic acid [for other ailments] started reporting to their doctors that their melasma started improving while taking the drug

It is well known that pain is a common clinical sign related to the inflammatory process, and O 3 therapy might play a key role in the modulation of nociceptive pain perception [11, 42]