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That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

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Safety AOD 9604 was developed as part of an effort to create a growth hormonederived treatment with fat-burning benefits but no anabolic effects

The study established that AOD9604 mediates its fat-reducing effects through 3-AR upregulation and ACC inhibition, independent of the insulin-like growth factor (IGF-1) axis, which distinguishes its mechanism from full-length hGH

When NNMT is active, it slows fat breakdown, making your body use energy less efficiently