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Do not refrigerate unless the label suggests it, as condensation from refrigeration can damage the capsule shell or allow moisture in

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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

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Behaviorally, BALB/c mice display elevated anxiety and reduced social interaction compared to other strains, traits that mirror emotional (Mehla et al., 2022) and behavioral changes often observed in Alzheimers patients, such as anxiety, impaired social interaction, and disinhibition (Mitrea et al., 2022)