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Sexually dimorphic actions of glucocorticoids provide a link to inflammatory diseases with gender differences in prevalence

Too diluted larger volumes required, making handling less efficient

The metabolic underpinnings of ferroptosis

I'd add an evolutionary lens to this discussion - if we consider that humans are hypercarnivores based on our digestive anatomy and evolutionary history, "insulin resistance" becomes less about pathology and more about normal physiology responding to an unnatural food environment